tailieunhanh - báo cáo khoa học: " Molecular imaging of potential bone metastasis from differentiated thyroid cancer: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Molecular imaging of potential bone metastasis from differentiated thyroid cancer: a case report | Sandu et al. Journal of Medical Case Reports 2011 5 522 http content 5 1 522 JOURNALOF medical case reports CASE REPORT Open Access Molecular imaging of potential bone metastasis from differentiated thyroid cancer a case report 12 3 4 T- I- 1 1 Nora Sandu Gabriele Popperl Marie-Elisabeth Toubert Belachew Arasho Toma Spiriev Mikael Orabi and Bernhard J Schaller1 5 Abstract Introduction Molecular imaging of the spine is a rarely used diagnostic method for which only a few case reports exist in the literature. Here to the best of our knowledge we present the first case of a combination of molecular imaging by single photon emission computer tomography and positron emission tomography used in postoperative spinal diagnostic assessment. Case presentation We present the case of a 50-year-old Caucasian woman experiencing progressive spinal cord compression caused by a vertebral metastasis of a less well differentiated thyroid cancer. Following tumor resection and vertebral stabilization total thyroidectomy was performed revealing follicular thyroid carcinoma pT2 pNxM1 lung bone . During follow-up our patient underwent five radioiodine therapy procedures to GBq each over a two-year period. Post-therapeutic I-131 scans showed decreasing uptake in multiple Pulmonary metastases. However following an initial decrease stimulated thyroglobulin remained at pathologically increased levels indicating further neoplastic activity. F18 Fludeoxyglucose positron emission tomography which was performed in parallel showed remaining hypermetabolism in the lungs but no hypermetabolism of the spinal lesions correlating with the stable neurological examinations. While on single photon emission computer tomography images Pulmonary hyperfixation of I-131 disappeared most likely indicating dedifferentiation there was persistent spinal hyperfixation at the operated level and even higher fixation at the spinal process of L3. Based on the negative results of