tailieunhanh - báo cáo khoa học: " A rare occurrence of a steroid cell tumor of the pelvic mesentery: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:A rare occurrence of a steroid cell tumor of the pelvic mesentery: a case report | Murhekar et al. Journal of Medical Case Reports 2011 5 517 http content 5 1 517 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access A rare occurrence of a steroid cell tumor of the pelvic mesentery a case report Kanchan Murhekar1 Robert Louis2 and Urmila Majhi1 Abstract Introduction Steroid cell tumors are microscopically characterized by abundant eosinophilic or vacuolated cytoplasm that is often positive for fat stains. These tumors could be of ovarian or ectopic adrenal origin. We present a rare case of a steroid cell tumor arising from the pelvic mesentery. Case presentation A 31-year-old Asian woman was undergoing treatment for infertility and virilizing symptoms. She underwent laparoscopy followed by laprotomy for a suspected ovarian cyst pelvic mass. During the laprotomy a mass of 9 X 7 cm was detected in the pelvic mesentery. Microscopically the tumor showed large cells arranged predominantly in sheets with abundant granular cytoplasm and large vesicular nuclei with prominent nucleoli. The tumor was seen infiltrating surrounding adipose tissue. Immunohistochemically the tumor cells showed strong positivity for kertain inhibin vimentine melan-A neuronspecific enolase chromogranin and S-100 protein and focal positivity to epithelial membrane antigen. An MIB1 index showed 4 nuclear positivity. The tumor cells were negative for calretinin desmin and muscle actin. Considering the clinical findings histomorphology and immunohistochemistry we made the diagnosis of extraovarian and extra-adrenal steroid cell tumor not otherwise specified of the pelvic mesentery. Conclusions We report an extremely rare case of an extraovarian and extra-adrenal steroid cell tumor of the pelvic mesentery. The tumor was a cause of virilizing symptoms and infertility in the patient. Surgical removal of the tumor reverted the symptoms of virilization and the patient subsequently conceived. Steroid cell tumors should be considered in differential diagnosis

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