tailieunhanh - báo cáo khoa học: "Hypocellular scar formation or aberrant fibrosis induced by an intrastromal corneal ring: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Hypocellular scar formation or aberrant fibrosis induced by an intrastromal corneal ring: a case report | Cao et al. Journal of Medical Case Reports 2011 5 398 http content 5 1 398 JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Hypocellular scar formation or aberrant fibrosis induced by an intrastromal corneal ring a case report Xiaoguang Cao1 2 Roxana Ursea3 Defen Shen 1 Hema L Ramkumar1 4 and Chi-Chao Chan1 Abstract Introduction Intrastromal corneal rings or segments are approved for the treatment of myopia and astigmatism associated with keratoconus. We describe a clinicopathological case of intrastromal corneal rings. For the first time the molecular pathological findings of intrastromal corneal rings in the cornea are illustrated. Case presentation A 47-year-old African-American man with a history of keratoconus and failure in using a Rigid Gas Permeable contact lens received an intrastromal corneal ring implant in his left eye. Due to complications penetrating keratoplasty was performed. The intrastromal corneal ring channels were surrounded by a dense acellular channel haze and or hypocellular acidophilic densification collagen scar and slightly edematous keratocytes. Mild macrophage infiltration was found near the inner aspect of the intrastromal corneal rings. Molecular analyses of the microdissected cells surrounding the intrastromal corneal ring channels and central corneal stroma revealed 10 times lower relative expression of IP-10 CXCL10 mRNA and two times higher CCL5 mRNA in the cells surrounding the intrastromal corneal ring as compared to the central corneal stroma. IP-10 CXCL10 is a fibrotic and angiostatic chemokine produced by macrophages endothelial cells and fibroblasts. Conclusion An intrastromal corneal ring implant can induce hypocellular scar formation and mild inflammation which may result from aberrant release of fibrosis-related chemokines. Introduction Intrastromal corneal ring segments Intacs KeraVision Inc. Fremont CA USA which have been approved for the treatment of myopia and astigmatism associated