tailieunhanh - Báo cáo y học: "Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide. | Available online http content 11 6 R167 Research article Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide Keiichi Iwanami1 Isao Matsumoto1 2 Yohei Yoshiga1 Asuka Inoue1 Yuya Kondo1 Kayo Yamamoto1 Yoko Tanaka1 Reiko Minami1 Taichi Hayashi1 Daisuke Goto1 Satoshi Ito1 Yasuharu Nishimura3 and Takayuki Sumida1 Department of Clinical Immunology Doctoral Program in Clinical Science Graduate School of Comprehensive Human Science University of Tsukuba 1-1-1 Tennoudai Tsukuba 305-8575 Japan 2PRESTO Japan Science and Technology Agency 4-1-8 Honcho Kawaguchi Saitama 332-0012 Japan department of Immunogenetics Graduate School of Medical Sciences Kumamoto University 2-39-1 Kurokami Kumamoto 860-8556 Japan Corresponding author Isao Matsumoto ismatsu@ Received 4 May 2009 Revisions requested 2 Jul 2009 Revisions received 23 Sep 2009 Accepted 9 Nov 2009 Published 9 Nov 2009 Arthritis Research Therapy 2009 11 R167 doi 86 ar2854 This article is online at http content 11 6 R167 2009 Iwanami et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Immunosuppressants including anti-TNFa antibodies have remarkable effects in rheumatoid arthritis however they increase infectious events. The present study was designed to examine the effects and immunological change of action of altered peptide ligands APLs on glucose-6-phosphate isomerase GPI peptide-induced arthritis. Methods DBA 1 mice were immunized with and cells of draining lymph node DLN were stimulated with to investigate the T-cell receptor TCR repertoire of antigen-specific CD4 T cells by flow cytometry. Twenty types of APLs .