tailieunhanh - Báo cáo y học: "Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model. | Available online http content 11 6 R166 Research article Effect of small interference RNA siRNA for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model Shoji Seki1 Yumiko Asanuma-Abe1 2 Koichi Masuda3 Yoshiharu Kawaguchi1 Kunihiro Asanuma2 Carol Muehleman4 Akiko Iwai1 and Tomoatsu Kimura1 Open Access department of Orthopaedic Surgery Faculty of Medicine University of Toyama 2630 Sugitani Toyama Toyama 930-0194 Japan department of Orthopedic Surgery Rush Medical College at Rush University Medical Center 1 653 W Congress Parkway Chicago IL 60612 USA department of Orthopaedic Surgery School of Medicine University of California San Diego 9500 Gilman Drive Mail Code 0863 La Jolla CA 92093-0863 USA department of Biochemistry Rush Medical College at Rush University Medical Center 1653 W Congress Parkway Chicago IL 60612 USA Corresponding author Shoji Seki seki@ Received 21 Aug 2009 Revisions requested 16 Sep 2009 Revisions received 10 Oct 2009 Accepted 4 Nov 2009 Published 4 Nov 2009 Arthritis Research Therapy 2009 11 R166 doi ar2851 This article is online at http content 11 6 R166 2009 Shoji Seki et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The etiology of degenerative disc disease is unknown. Several investigators have reported the presence of proteolytic enzymes such as the matrix metalloproteinase MMP and ADAMTS a disintegrin and metalloprotease with thrombospondin-like repeats families in degenerated human discs. Glasson and colleagues recently reported that a significant reduction occurs in the severity of cartilage destruction in ADAMTS5 knockout mice compared with wildtype mice. The .