tailieunhanh - báo cáo khoa học: " Legionella pneumophila serogroup 3 pneumonia in a patient with low-grade 4 non-Hodgkin lymphoma: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Legionella pneumophila serogroup 3 pneumonia in a patient with low-grade 4 non-Hodgkin lymphoma: a case report | Mencacci et al. Journal of Medical Case Reports 2011 5 387 http content 5 1 387 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Legionella pneumophila serogroup 3 pneumonia in a patient with low-grade 4 non-Hodgkin lymphoma a case report Antonella Mencacci1 Cristina Corbucci1 Alessio Castellani2 Paolo Furno2 Francesco Bistoni1 and Anna Vecchiarelli1 Abstract Introduction Nosocomial legionellosis has generally been described in immunodepressed patients but Legionella pneumophila serogroup 3 has rarely been identified as the causative agent. Case presentation We report the case of nosocomial L. pneumophila serogroup 3 pneumonia in a 70-year-old Caucasian man with non-Hodgkin lymphoma. Diagnosis was carried out by culture and real-time polymerase chain reaction of bronchoalveolar lavage fluid. The results of a urinary antigen test were negative. A hospital environmental investigation revealed that the hospital water system was highly colonized by L. pneumophila serogroups 3 4 and 8. The hospital team involved in the prevention of infections was informed long-term control measures to reduce the environmental bacterial load were adopted and clinical monitoring of legionellosis occurrence in high-risk patients was performed. No further cases of Legionella pneumonia have been observed so far. Conclusions In this report we describe a case of legionellosis caused by L. pneumophila serogroup 3 which is not usually a causative agent of nosocomial infection. Our research confirms the importance of carrying out cultures of respiratory secretions to diagnose legionellosis and highlights the limited value of the urinary antigen test for hospital infections especially in immunocompromised patients. It also indicates that to reduce the bacterial load and prevent nosocomial legionellosis appropriate control measures should be implemented with systematic monitoring of hospital water systems. Introduction Legionnaires disease is often a .