tailieunhanh - Báo cáo y học: "Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis. | Available online http content 11 6 255 Review Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis Michael F Smith Jr1 2 Falk Hiepe3 Thomas Dorner3 and Gerd Burmester3 1Wyeth Research Discovery Translational Medicine Collegeville PA 19426 USA 2Present address Hoffmann-La Roche Inc. 340 Kingsland Street Building 721 Nutley NJ 07110 USA 3Universitatsmedizin Charité Berlin 10098 Berlin Germany Corresponding author Michael F Smith Published 19 November 2009 This article is online at http content 11 6 255 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 255 doi ar2834 Abstract One of the major challenges in rheumatology is to overcome the classification criteria that previously defined systemic lupus erythematosis since the heterogeneity of the disease s appears to represent a complexity that probably substantially contributed to the failure of a number of recent trials. For those engaged in clinical trials validated disease activity biomarkers that respond rapidly to treatment and are predictive of clinical response would greatly facilitate early decision-making around futility and dose selection. Likewise use of validated patient stratification biomarkers possibly in conjunction with autoantibody profiles and disease manifestations will result in the recruitment of more homogeneous patient populations during later stage clinical studies thereby decreasing size costs and risks in pivotal studies. Challenge of lupus for drug development Systemic lupus erythematosis SLE is perhaps the most clinically and serologically diverse of the autoimmune diseases. The current American College of Rheumatology classification lists 11 criteria for diagnosis of lupus of which a patient must meet four 1 . The heterogeneity of the patient population results in significant challenges not only in classifying disease activity but also for .

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