tailieunhanh - báo cáo khoa học: "Mycobacterium chimaera pulmonary infection complicating cystic fibrosis: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Mycobacterium chimaera pulmonary infection complicating cystic fibrosis: a case report | Cohen-Bacrie et al. Journal of Medical Case Reports 2011 5 473 http content 5 1 473 JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Mycobacterium chimaera pulmonary infection complicating cystic fibrosis a case report 3 3 3 Stéphan Cohen-Bacrie Marion David Nathalie Stremler Jean-Christophe Dubus Jean-Marc Rolain and Michel Drancourt1 2 Abstract Background Mycobacterium chimaera is a recently described species within the Mycobacterium avium complex. Its pathogenicity in respiratory tract infection remains disputed. It has never been isolated during cystic fibrosis respiratory tract infection. Case presentation An 11-year-old boy of Asian ethnicity who was born on Réunion Island presented to our hospital with cystic fibrosis after a decline in his respiratory function over the course of seven years. We found that the decline in his respiratory function was correlated with the persistent presence of a Mycobacterium avium complex organism further identified as M. chimaera. Conclusion Using sequencing-based methods of identification we observed that M. chimaera organisms contributed equally to respiratory tract infections in patients with cystic fibrosis when compared with M. avium subsp. hominissuis isolates. We believe that M. chimaera should be regarded as an emerging opportunistic respiratory pathogen in patients with cystic fibrosis including young children and that its detection warrants long-lasting appropriate anti-mycobacterial treatment to eradicate it. Introduction Mycobacterium avium complex MAC organisms are opportunistic pathogens and their isolation from the respiratory tract of cystic fibrosis CF patients correlates with declining respiratory function 1 . Six of nine MAC species have been described in the past five years 2-4 but the spectrum of MAC organisms infecting CF patients is not well established only M. avium and Mycobacterium intracellulare have been reported in these patients 1 5 . Our reference .

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