tailieunhanh - Báo cáo y học: "Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells. | Available online http content 11 5 R151 Research article Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells Franco Capsoni1 Anna Maria Ongari1 Eva Reali2 and Anna Catania3 Open Access Rheumatology Unit Istituto Ortopedico Galeazzi IRCCS Istituto Di Ricovero e Cura a Carattere Scientifico University of Milan Via Riccardo Galeazzi 4 20161 Milan Italy 2INGM-National Institute of Molecular Genetics Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena Via Francesco Sforza 28 20122 Milan Italy 3Center for Preclinical Investigation Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena Via Francesco Sforza 28 20122 Milan Italy Corresponding author Franco Capsoni Received 22 Apr 2009 Revisions requested 18 May 2009 Revisions received 18 Sep 2009 Accepted 8 Oct 2009 Published 8 Oct 2009 Arthritis Research Therapy 2009 11 R151 doi 86 ar2827 This article is online at http content 11 5 R151 2009 Capsoni et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The melanocortin peptides have marked antiinflammatory potential primarily through inhibition of proinflammatory cytokine production and action on phagocytic cell functions. Gout is an acute form of arthritis caused by the deposition of urate crystals in which phagocytic cells and cytokines play a major pathogenic role. We examined whether alpha-melanocyte-stimulating hormone a-MSH and its synthetic derivative CKPV 2 influence urate crystal-induced monocyte Mo activation and neutrophil responses in vitro. Methods Purified Mos were stimulated with monosodium urate MSU crystals in the presence or absence of .