tailieunhanh - báo cáo khoa học: "Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report | Tisman and Garcia Journal of Medical Case Reports 2011 5 413 http content 5 1 413 JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Control of prostate cancer associated with withdrawal of a supplement containing folic acid L-methyltetrahydrofolate and vitamin B12 a case report Glenn Tisman and April Garcia Abstract Introduction This is the first report of possible direct stimulation of hormone-resistant prostate cancer or interference of docetaxel cytotoxicity of prostate cancer in a patient with biochemical relapse of prostatic-specific antigen. This observation is of clinical and metabolic importance especially at a time when more than 80 countries have fortified food supplies with folic acid and some contemplate further fortification with vitamin B12. Case presentation Our patient is a 71-year-old Caucasian man who had been diagnosed in 1997 with prostate cancer stage T1c and Gleason score 3 4 7. His primary treatment included intermittent androgen deprivation therapy including leuprolide bicalutamide deutasteride ketoconazole hydrocortisone nilandrone and flutamide to resistance defined as biochemical relapse of PSA. While undergoing docetaxel therapy to treat a continually increasing prostate-specific antigen level withdrawal of 10 daily doses of a supplement containing 500 pg of vitamin B12 as cyanocobalamin as well as 400 pg of folic acid as pteroylglutamic acid and 400 pg of L-5-methyltetrahydrofolate for a combined total of 800 pg of mixed folates was associated with a return to a normal serum prostatic-specific antigen level. Conclusion This case report illustrates the importance of the effects of supplements containing large amounts of folic acid L-5-methyltetrahydrofolate and cyanocobalamin on the metabolism of prostate cancer cells directly and or B vitamin interference with docetaxel efficacy. Physicians caring for patients with prostate cancer undergoing watchful waiting hormone therapy and or chemotherapy should