tailieunhanh - Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis. | Available online http content 11 2 R57 Open Access Research article Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis Valérie Badot1 2 Christine Galant3 Adrien Nzeusseu Toukap1 Ivan Theate3 Anne-Lise Maudoux1 Benoit J Van den Eynde4 Patrick Durez1 Frédéric A Houssiau1 and Bernard R Lauwerys1 Rheumatology Department Cliniques Universitaires Saint-Luc Université catholique de Louvain Avenue Hippocrate 10 B-1200 Brussels Belgium 2Rheumatology Department CHU Brugmann Place Arthur Van Gehuchten 4 1020 Brussels Belgium 3Pathology Department Cliniques Universitaires Saint-Luc Université catholique de Louvain Avenue Hippocrate 10 B-1 200 Brussels Belgium 4Ludwig Institute for Cancer Research Avenue Hippocrate 74 B-1 200 Brussels Belgium Corresponding author Bernard R Lauwerys Received 5 Oct 2008 Revisions requested 2 Dec 2008 Revisions received 7 Mar 2009 Accepted 23 Apr 2009 Published 23 Apr 2009 Arthritis Research Therapy 2009 11 R57 doi ar2678 This article is online at http content 11 2 R57 2009 Badot et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction To identify markers and mechanisms of resistance to adalimumab therapy we studied global gene expression profiles in synovial tissue specimens obtained from severe rheumatoid arthritis RA patients before and after initiation of treatment. Methods Paired synovial biopsies were obtained from the affected knee of 25 DMARD disease-modifying antirheumatic drug -resistant RA patients at baseline T0 and 12 weeks T12 after initiation of adalimumab therapy. DAS28-CRP disease activity score