tailieunhanh - Báo cáo y học: "Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis. | Available online http content 11 3 R91 Open Access Research article Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response extra-articular symptoms and joint erosion in rheumatoid arthritis Manuela Rossol1 Matthias Pierer1 Sybille Arnold1 Gernot KeyBer2 Harald Burkhardt3 Christoph Baerwald1 and Ulf Wagner1 Division of Rheumatology Department of Internal Medicine II University of Leipzig Johannisallee 30 04103 Leipzig Germany 2Department of Internal Medicine I University of Halle Saale Ernst-Grube-StraBe 40 06120 Halle Saale Germany 3Division of Rheumatology Department of Internal Medicine II Johann Wolfgang Goethe University Frankfurt am Main Theodor-Stern-Kai 7 60590 Frankfurt am Main Germany Corresponding author Manuela Rossol Received 5 Dec 2008 Revisions requested 13 Jan 2009 Revisions received 8 May 2009 Accepted 18 Jun 2009 Published 18 Jun 2009 Arthritis Research Therapy 2009 11 R91 doi ar2733 This article is online at http content 11 3 R91 2009 Rossol et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Chemokines and their receptors control immune cell migration during infections as well as in autoimmune responses. A 32 bp deletion in the gene of the chemokine receptor CCR5 confers protection against HIV infection but has also been reported to decrease susceptibility to rheumatoid arthritis RA . The influence of this deletion variant on the clinical course of this autoimmune disease was investigated. Methods Genotyping for CCR5d32 was performed by PCR and subsequent electrophoretic fragment length determination. For the clinical analysis the following