tailieunhanh - Báo cáo y học: " Serum levels of hyaluronic acid and chondroitin sulfate as a non-invasive method to evaluate healing after cartilage repair procedures"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Serum levels of hyaluronic acid and chondroitin sulfate as a non-invasive method to evaluate healing after cartilage repair procedures. | Available online http content 11 4 118 Editorial Serum levels of hyaluronic acid and chondroitin sulfate as a non-invasive method to evaluate healing after cartilage repair procedures Andreas H Gomoll Department of Orthopedic Surgery Brigham and Women s Hospital Harvard Medical School 75 Francis Street Boston MA 02115 USA Corresponding author Andreas H Gomoll agomoll@ Published 3 July 2009 Arthritis Research Therapy 2009 11 118 doi ar2730 This article is online at http content 11 4 118 2009 BioMed Central Ltd See related research by Nganvongpanit et al. http content 11 3 R78 Abstract Magnetic resonance imaging remains the only non-invasive method to assess the quality of cartilage repair procedures but ideally would be complemented by other modalities particularly blood tests. Nganvongpanit and colleagues investigated serum levels of hyaluronic acid HA and chondroitin sulfate CS for their correlation with tissue quality after cartilage repair with autologous chondrocytes versus subchondral drilling in a dog model. They reported better tissue quality in animals treated with chondrocyte implantation. Serum levels correlated with the histological score of biopsy samples CS showed a negative r and HA a positive r correlation. Many questions remain to be answered before serum markers can provide a reliable non-invasive tool to assess tissue quality but these data provide an important foundation for additional research. In the previous issue of Arthritis Research Therapy Nganvongpanit and colleagues 1 of Chiang Mai University in Thailand investigated the potential use of serum biomarkers such as hyaluronic acid HA and chondroitin sulfate CS to evaluate healing after cartilage repair procedures. They randomly assigned dogs to treatment with autologous chondrocyte implantation ACI versus subchondral drilling SD and followed the animals for 24 weeks post-operatively with .