tailieunhanh - Báo cáo y học: "Anti-C1q antibodies antedate patent active glomerulonephritis in patients with systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Anti-C1q antibodies antedate patent active glomerulonephritis in patients with systemic lupus erythematosus. | Available online http content 11 3 R87 Research article Anti-C1q antibodies antedate patent active glomerulonephritis in patients with systemic lupus erythematosus Olivier C Meyer1 Pascale Nicaise-Roland2 Nolwenn Cadoudal2 Sabine Grootenboer-Mignot2 Elisabeth Palazzo1 Gilles Hayem1 Philippe Dieudé1 and Sylvie Chollet-Martin2 Rheumatology Unit Bichat Hospital APHP 46 rue Henri Huchard 75018 Paris France 2Immunology Unit Bichat Hospital APHP 46 rue Henri Huchard 75018 Paris France Corresponding author Olivier C Meyer Received 28 Jan 2009 Revisions requested 20 Feb 2009 Revisions received 5 Jun 2009 Accepted 10 Jun 2009 Published 10 Jun 2009 Arthritis Research Therapy 2009 11 R87 doi ar2725 This article is online at http content 11 3 R87 2009 Meyer et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Autoantibodies against C1q correlate with lupus nephritis. We compared titers of anti-C1q and anti-dsDNA in 70 systemic lupus erythematosus patients with n 15 or without n 55 subsequent biopsy-proven lupus nephritis. Methods The 15 patients with subsequent lupus nephritis had anti-C1q assays during clinical flares mean Systemic Lupus Erythematosus Disease Activity Index SLEDAI range 3 to 22 before the diagnosis of lupus nephritis median 24 months range 3 to 192 . Among the 55 others 33 patients had active lupus mean SLEDAI range 4 to 30 without renal disease during follow-up median 13 years range 2 to 17 years and 22 had inactive lupus mean SLEDAI 0 range 0 to 3 . Results Anti-C1q titers were elevated in 15 15 100 patients who subsequently developed nephritis class IV n 14 class V n 1 and in 15 33 .