tailieunhanh - Báo cáo y học: "Immunopathogenesis of spondyloarthritis: which cells drive disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Immunopathogenesis of spondyloarthritis: which cells drive disease? | Available online http content 11 3 233 Review Progress in spondylarthritis Immunopathogenesis of spondyloarthritis which cells drive disease Lode Melis and Dirk Elewaut Department of Rheumatology Ghent University Hospital 0K12IB De Pintelaan 185 9000 Ghent Belgium Corresponding author Dirk Elewaut Published 25 June 2009 This article is online at http eontent 11 3 233 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 233 doi ar2722 Abstract Spondyloarthritides or SpA form a cluster of chronic inflammatory diseases with the axial skeleton as the most typical disease localisation although extra-articular manifestations such as intestinal inflammation may frequently occur during the course of the disease. This review summarises recent progress in our understanding of the immunopathogenesis of SpA with special emphasis on the cellular constituents considered to be responsible for the initiation and or perpetuation of inflammation. There are several arguments favouring a role for haematopoietic cells in the pathophysiology of spondyloarthritis including HLA-B27-asso-ciated dendritic cell disturbances HLA-B27 misfolding properties and T helper 17 cells. In addition recent studies have pointed toward a pivotal role for stromal cells. A major challenge however remains to determine how recently identified genetic associations such as interleukin-23 receptor polymorphisms may influence cellular targets in spondyloarthritis. Introduction Spondyloarthritides or SpA are a group of chronic inflammatory diseases that affect about of the Western population. The most typical disease localisation is the axial skeleton more specifically the spine and sacroiliac joints. Additionally enthesitis or peripheral arthritis of the large joints of the lower limbs frequently occurs. Extra-articular manifestations are also a common feature in SpA. They include anterior uveitis psoriasis and inflammatory .

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.