tailieunhanh - Báo cáo y học: "Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids. | Available online http content 11 3 R83 Research article Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids Karina Roxana Gheorghe1 2 Marina Korotkova2 Anca Irinel Catrina2 Linda Backman3 Erik af Klint2 Hans-Erik Claesson3 4 Olof Râdmark4 and Per-Johan Jakobsson2 5 Open Access Department of Biosciences and Nutrition Novum Karolinska Institute SE-141 57 Huddinge Sweden department of Medicine Rheumatology Unit Karolinska University Hospital and Karolinska Institute S-171 76 Stockholm Sweden 3Orexo AB Virdings allé 32 A SE-751 05 Uppsala Sweden department of Medical Biochemistry and Biophysics Karolinska Institutet SE-171 77 Stockholm Sweden 5Karolinska Biomic Center Karolinska University Hospital and Karolinska Institute S-171 76 Stockholm Sweden Corresponding author Per-Johan Jakobsson Received 6 Jan 2009 Revisions requested 24 Feb 2009 Revisions received 6 May 2009 Accepted 4 Jun 2009 Published 4 Jun 2009 Arthritis Research Therapy 2009 11 R83 doi ar2717 This article is online at http content 11 3 R83 2009 Gheorghe et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction It was previously shown that lipoxygenase LO pathways are important in the rheumatoid arthritis RA inflammatory process and that synovial fluid from RA patients contains high amounts of leukotrienes. We therefore aimed to investigate the 5-LO and 15-LO-1 expression pattern in RA and ostheoarthritis OA synovial tissue and to study the effect of intraarticular glucocorticoid GC therapy on enzyme expression. Methods Expression of LOs was evaluated by immunohistochemistry in RA and OA .