tailieunhanh - APPLICATIONS OF MICRODIALYSIS IN PHARMACEUTICAL SCIENCE

Microdialysis is a very useful sampling tool that can be used in vivo to acquire concentration variations of protein - unbound molecules located in interstitial or extracellular spaces. This technique relies on the passive diffusion of substances across a dialysis membrane driven by a concentration gradient. After a microdialysis probe has been implanted in the target site for sampling, generally a blood vessel or tissue, a perfused solution consisting of physiological buffer solution fl ows slowly across the dialysis membrane, carrying away small molecules that come from the extracellular space on the other side of the dialysis membrane. The resulting dialysis solution can be analyzed to determine drug or. | APPLICATIONS OF MICRODIALYSIS IN PHARMACEUTICAL SCIENCE APPLICATIONS OF MICRODIALYSIS IN PHARMACEUTICAL SCIENCE Edited by TUNG-HU TSAI National Yang-Ming University Taipei Taiwan WILEY A JOHN WILEY SONS INC. PUBLICATION Copyright 2011 by John Wiley Sons Inc. All rights reserved. Published by John Wiley Sons Inc. Hoboken New Jersey. Published simultaneously in Canada. No part of this publication may be reproduced stored in a retrieval system or transmitted in any form or by any means electronic mechanical photocopying recording scanning or otherwise except as permitted under Section 107 or 108 of the 1976 United States Copyright Act without either the prior written permission of the Publisher or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center Inc. 222 Rosewood Drive Danvers MA 01923 978 750-8400 fax 978 750-4470 or on the web at . Requests to the Publisher for permission should be addressed to the Permissions Department John Wiley Sons Inc. 111 River Street Hoboken NJ 07030 201 748-6011 fax 201 748-6008 or online at http go permissions. Limit of Liability Disclaimer of Warranty While the publisher and author have used their best efforts in preparing this book they make no representations or warranties with respect to the accuracy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives or written sales materials. The advice and strategies contained herein may not be suitable for your situation. You should consult with a professional where appropriate. Neither the publisher nor author shall be liable for any loss of profit or any other commercial damages including but not limited to special incidental consequential or other damages. For general information on our other products and services or for technical support please contact our .