tailieunhanh - Báo cáo y học: "Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits. | Available online http content 10 6 R133 Open Access Research article Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits Toshiyuki Okura1 Kousuke Marutsuka2 Hiroaki Hamada1 Tomohisa Sekimoto1 Tsuyoshi Fukushima3 Yujiro Asada2 Kazuo Kitamura4 and Etsuo Chosa1 Division of Orthopedic Surgery Department of Medicine of Sensory and Motor Organs Faculty of Medicine University of Miyazaki 5200 Kihara Kiyotake Miyazaki 889-1692 Japan 2Section of Pathophysiology Department of Pathology Faculty of Medicine University of Miyazaki 5200 Kihara Kiyotake Miyazaki 889-1 692 Japan 3Section of Oncopathology and Regenerative Biology Department of Pathology Faculty of Medicine University of Miyazaki 5200 Kihara Kiyotake Miyazaki 889-1692 Japan 4Division of Circulatory and Body Fluid Regulation Department of Internal Medicine Faculty of Medicine University of Miyazaki 5200 Kihara Kiyotake Miyazaki 889-1692 Japan Corresponding author Etsuo Chosa chosa@ Received 12 Jun 2008 Revisions requested 17 Jul 2008 Revisions received 15 Oct 2008 Accepted 13 Nov 2008 Published 13 Nov 2008 Arthritis Research Therapy 2008 10 R133 doi 86 ar2550 This article is online at http content 10 6 R133 2008 Okura et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Adrenomedullin is a potent vasodilatory and hypotensive peptide as well as an endogenous immunomodulatory factor with predominantly anti-inflammatory effects. The purpose of the present study was to evaluate the therapeutic effects of adrenomedullin in rabbits with antigen-induced arthritis an experimental model of rheumatoid arthritis. Methods Following the .