tailieunhanh - Báo cáo y học: " Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilag"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage. | Available online http content 11 3 R80 Research article Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage Susana C Rosa1 Juliana Gonọalves1 Fernando Judas2 Ali Mobasheri3 Celeste Lopes1 and Alexandrina F Mendes1 Center for Neurosciences and Cell Biology and Faculty of Pharmacy University of Coimbra 3004-517 Coimbra Portugal 2Orthopaedics Department University Hospital of Coimbra Avenida Bissaya Barreto Bloco de Celas 3000-075 Coimbra Portugal 3Division of Veterinary Medicine School of Veterinary Science and Medicine Sutton Bonington Campus University of Nottingham Sutton Bonington LE12 5RD UK Corresponding author Alexandrina F Mendes afmendes@ Received 26 Nov 2008 Revisions requested 21 Jan 2009 Revisions received 29 Apr 2009 Accepted 2 Jun 2009 Published 2 Jun 2009 Arthritis Research Therapy 2009 11 R80 doi ar2713 This article is online at http content 11 3 R80 2009 Rosa et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Disorders that affect glucose metabolism namely diabetes mellitus DM may favor the development and or progression of osteoarthritis OA . Thus far little is known regarding the ability of chondrocytes to adjust to variations in the extracellular glucose concentration resulting from hypoglycemia and hyperglycemia episodes and so to avoid deleterious effects resulting from deprivation or intracellular accumulation of glucose. The aim of this study was to compare the ability of normal and OA chondrocytes to regulate their glucose transport capacity in conditions of .