tailieunhanh - Báo cáo y học: "Stress of different types increases the proinflammatory load in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Stress of different types increases the proinflammatory load in rheumatoid arthritis. | Available online http content 11 3 114 Editorial Stress of different types increases the proinflammatory load in rheumatoid arthritis Rainer H Straub1 and Joachim R Kalden2 1 Laboratory of Experimental Rheumatology and Neuroendocrino-Immunology Division of Rheumatology Department of Internal Medicine I University Hospital 93042 Regensburg Germany 2Department of Medicine 3 University of Erlangen-Nuremberg Nikolaus-Fiebiger-Center 91054 Erlangen Germany Corresponding author Rainer H Straub Published 17 June 2009 Arthritis Research Therapy 2009 11 114 doi ar2712 This article is online at http content 11 3 114 2009 BioMed Central Ltd See related research by Edwards et al. http content 11 3 R61 Abstract Stress in patients with chronic inflammatory diseases such as rheumatoid arthritis RA stimulates proinflammatory mechanisms due to the defect of stress response systems for example the sympathetic nervous system and the hypothalamic-pituitaryadrenal axis . Among other mechanisms the loss of sympathetic nerve fibers in inflamed tissue and inadequate cortisol secretion in relation to inflammation lead to an enhanced proinflammatory load in RA. Stress and the subsequent stimulation of inflammation systemic and local lead to increased sensitization of pain and further defects of stress response systems vicious cycle of stress pain and inflammation . In 1937 Hans Selye called the activation of stress systems an alarm reaction which is the reaction of an organism when first confronted with a stimulus to which it is quantitatively or qualitatively not adapted . Until the beginning of the 1980s the stress systems including the sympathetic nervous system SNS and the hypothalamic-pituitary-adrenal axis were thought to play a proinflammatory role by supporting the immune response. This view was markedly changed in the years thereafter when targeted experiments with .