tailieunhanh - báo cáo khoa học: "Adenoid cystic carcinoma intermingled with ductal carcinoma of the breast: a case report and review of the literature"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Adenoid cystic carcinoma intermingled with ductal carcinoma of the breast: a case report and review of the literature | Kontos et al. Journal of Medical Case Reports 2011 5 437 http content 5 1 437 JOURNALOF medical case reports CASE REPORT Open Access Adenoid cystic carcinoma intermingled with ductal carcinoma of the breast a case report and review of the literature Michael Kontos1 Dimitrios Karles1 Athanasios Petrou1 and Paraskevi TH Alexandrou2 Abstract Introduction Adenoid cystic cancer of the breast is a rare condition and even rarer are the cases where it is histologically mixed with other variants of cancer within a single lesion. In this report one of the few cases of mixed adenoid cystic breast cancer intermingled with the infiltrating ductal variant is presented. A subsequent review of the relevant literature presents the existing experience in treating mixed breast cancers with adenoid cystic components with regard to diagnosis treatment and prognosis. Case presentation We describe a case of mixed adenoid cystic cancer of the breast with infiltrating ductal carcinoma in a 67-year-old Caucasian woman who underwent mastectomy with sentinel node biopsy. Conclusion Surgery remains the cornerstone of treatment of these patients and radiotherapy is administered when breast-conserving treatment is undertaken or a large tumor with affected lymph nodes is present. Hormonal treatment does not have a role as estrogen receptors are always absent from both tumor components. Chemotherapy is nearly always administered on the basis of estrogen receptor and progesterone negativity and the more aggressive potential of the non-adenoid cystic component. The de-differentiation of an indolent type of cancer to a more aggressive one may affect the prognosis. Introduction Adenoid cystic carcinoma ACC of the breast is a rare type of breast cancer accounting for approximately of all mammary tumors 1 2 . This histologic variant of cancer is commonly found in the salivary glands where it bears an adverse prognosis. On the contrary breast ACC usually presents a .