tailieunhanh - Báo cáo y học: "Plasma gelsolin as a biomarker of inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Plasma gelsolin as a biomarker of inflammation. | Available online http content 10 6 124 Editorial Plasma gelsolin as a biomarker of inflammation Mark J DiNubile Division of Vaccines Infectious Diseases Medical Communications Department Merck Research Laboratories PO Box 1000 UG3C-06 North Wales PA 19454-1099 USA Corresponding author Mark J DiNubile mark_dinubile@ Published 3 December 2008 This article is online at http content 10 6 124 2008 BioMed Central Ltd Arthritis Research Therapy 2008 10 124 doi ar2547 See related research article by Osborn et al. http content 10 5 R117 Abstract The prognostic implications of declining plasma gelsolin levels have been documented after a diverse variety of acute insults. Because gelsolin concentrations fall prior to the development of complications a pathophysiological role for gelsolin depletion has been postulated in delayed multiorgan failure. The original hypothesis about the function of circulating gelsolin was that it scavenged actin released from cells at the site of injury. Although extracellular actin may be the primary cause of gelsolin depletion the biologic imperative for gelsolin could entail the modulation of several inflammatory mediators as much as the disposal of actin. Translational research is actively addressing whether replenishment of plasma gelsolin could provide an efficacious and well tolerated therapeutic intervention in selected seriously ill patients. Osborn and colleagues demonstrate that patients with rheumatoid arthritis and knee effusions have plasma gelsolin levels lower than those in healthy volunteers 1 . Gelsolin was first identified as a cytoplasmic actin-regulatory protein essential for cell locomotion and phagocytosis. When a circulating isoform was subsequently discovered its physiological significance was far from apparent. For over two decades researchers have struggled to define the raison d etre for actin-binding proteins in plasma which under .