tailieunhanh - Báo cáo y học: "Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment. | Available online http content 10 5 R125 Research article Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment Heiner Appel1 Louise Janssen1 Joachim Listing2 René Heydrich1 Martin Rudwaleit1 and Joachim Sieper1 2 Department of Gastroenterology Infectiology and Rheumatology Charité Berlin Campus Benjamin Franklin Hindenburgdamm 30 1 2203 Berlin Germany 2Deutsches Rheumaforschungszentrum Berlin Schumannstrassse 21 22 10117 Berlin Germany Corresponding author Heiner Appel Received 7 Aug 2008 Revisions requested 8 Sep 2008 Revisions received 8 Oct 2008 Accepted 22 Oct 2008 Published 22 Oct 2008 Arthritis Research Therapy 2008 10 R125 doi 86 ar2537 This article is online at http content 10 5 R1 25 2008 Appel et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Recent data about radiographic progression during treatment with tumor necrosis factor-alpha TNF-a blocker agents in patients with ankylosing spondylitis AS have prompted an intensive discussion about the link between inflammation bone destruction and new bone formation and the order of events. Therefore we analysed parameters of cartilage degradation neoangiogenesis and new bone formation in different cohorts of patients with axial spondyloarthritis with and without treatment with TNF-a blocker agents. Method TNF-a blocker-naive AS patients were investigated for serum levels of metalloproteinase-3 MMP-3 n 71 vasoendothelial growth factor VEGF n 50 and bonespecific alkaline phosphatase BALP n 71 at baseline and

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