tailieunhanh - Báo cáo y học: " Toll-like receptor homolog RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Toll-like receptor homolog RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis. | Available online http content 10 5 R121 Research article Toll-like receptor homolog RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis Yoshifumi Tada1 Syuichi Koarada1 Fumitaka Morito1 Mio Mitamura1 Hisako Inoue1 Rie Suematsu1 Akihide Ohta2 Kensuke Miyake3 and Kohei Nagasawa1 Department of Internal Medicine Saga Medical School 5-1-1 Nabeshima Saga 849-8501 Japan department of Clinical Nursing Saga Medical School 5-1-1 Nabeshima Saga 849-8501 Japan division of Infectious Genetics Institute of Medical Science University of Tokyo 4-6-1 Shirokanedai Minato-ku Tokyo 1 08-8639 Japan Corresponding author Yoshifumi Tada taday@ Received 7 Mar 2008 Revisions requested 14 May 2008 Revisions received 26 Sep 2008 Accepted 11 Oct 2008 Published 11 Oct 2008 Arthritis Research Therapy 2008 10 R121 doi 86 ar2529 This article is online at http content 10 5 R121 2008 Tada et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction RP105 is a Toll-like receptor homolog expressed on B cells dendritic cells DCs and macrophages. We investigated the role of RP105 in the development of collagen-induced arthritis CIA . Methods CIA was induced in RP105-deficient DBA 1 mice and the incidence and arthritis index were analyzed. The cytokine production by spleen cells was determined. The functions of the DCs and regulatory T cells Tregs from RP105-deficient or control mice were determined by adding these cells to the lymph node cell culture. Arthritis was also induced by incomplete Freund s adjuvant IFA plus collagen or by injecting anticollagen antibody and lipopolysaccharide. Results .

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