tailieunhanh - Báo cáo y học: "Rationale for prostaglandin I2 in bone marrow oedema – from theory to application"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Rationale for prostaglandin I2 in bone marrow oedema – from theory to application. | Available online http content 10 5 R120 Research article Rationale for prostaglandin I2 in bone marrow oedema - from theory to application Marcus Jager1 3 Frank Peter Tillmann2 Thomas S Thornhill3 Marcus Mahmoudi1 Dirk Blondin4 Gerd Rudiger Hetzel2 Christoph Zilkens1 and Rudiger Krauspe1 Department of Orthopaedics Heinrich-Heine University Hospital Duesseldorf Moorenstrasse 5 D-40225 Duesseldorf Germany 2Clinic for Nephrology and Rheumatology Heinrich-Heine University Duesseldorf Moorenstrasse 5 D-40225 Duesseldorf Germany department of Orthopedic Surgery Brigham and Women s Hospital Harvard Medical School 75 Francis Street Boston MA 02115 USA 4Institute of Diagnostic Radiology Heinrich-Heine University Duesseldorf Moorenstrasse 5 D-40225 Duesseldorf Germany Corresponding author Marcus Jager Jaeger@ Received 25 Nov 2007 Revisions requested 29 Jan 2008 Revisions received 6 Sep 2008 Accepted 3 Oct 2008 Published 3 Oct 2008 Arthritis Research Therapy 2008 10 R120 doi 86 ar2526 This article is online at http content 10 5 R120 2008 Jager et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Bone marrow oedema BME and avascular osteonecrosis AVN are disorders of unclear origin. Although there are numerous operative and non-operative treatments for AVN pain management in patients with AVN remains challenging. Prostaglandins play an important role in inflammatory responses and cell differentiation. It is thought that prostaglandin I2 PGI2 or synonoma prostacyclin and its analogues promote bone regeneration on a cellular or systemic level. The purpose of this study was to assess the curative and symptomatic efficacy of the .