tailieunhanh - Báo cáo y học: "NOD-like receptors and inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: NOD-like receptors and inflammation. | Available online http content 10 6 228 Review NOD-like receptors and inflammation Rebeccah J Mathews1 Michael B Sprakes2 and Michael F McDermott1 Section of Musculoskeletal Disease Leeds Institute of Molecular Medicine St. James s University Hospital Beckett Street Leeds LS9 7TF UK 2Department of Gastroenterology Leeds General Infirmary Great George Street Leeds LSI 3EX UK Corresponding author Michael F McDermott Published 25 November 2008 This article is online at http content 10 6 228 2008 BioMed Central Ltd Arthritis Research Therapy 2008 10 228 doi ar2525 Abstract The nucleotide-binding and oligomerization domain leucine-rich repeat also known as NOD-like receptors both abbreviated to NLR family of intracellular pathogen recognition receptors are increasingly being recognized to play a pivotal role in the pathogenesis of a number of rare monogenic diseases as well as some more common polygenic conditions. Bacterial wall constituents and other cellular stressor molecules are recognized by a range of NLRs which leads to activation of the innate immune response and upregulation of key proinflammatory pathways such as IL-1 p production and translocation of nuclear factor-KB to the nucleus. These signalling pathways are increasingly being targeted as potential sites for new therapies. This review discusses the role played by NLRs in a variety of inflammatory diseases and describes the remarkable success to date of these therapeutic agents in treating some of the disorders associated with aberrant NLR function. Introduction Innate immunity plays a critical role in host protection and employs an array of receptor molecules including Toll-like receptors TLRs NOD-like receptors nucleotide-binding and oligomerization domain leucine-rich repeat both abbreviated to NLR retinoic acid-inducible gene-like receptors and C-type lectin receptors CLRs . Pathogen recognition receptors PRRs which serve to