tailieunhanh - Báo cáo y học: "Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination. | Available online http content 10 5 R119 Research article Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination Brian A Kidd1 2 3 Peggy P Ho4 Orr Sharpe1 2 Xiaoyan Zhao1 2 Beren H Tomooka1 2 Jennifer L Kanter4 Lawrence Steinman4 and William H Robinson1 2 Open Access Department of Medicine Division of Immunology and Rheumatology CCSR 4135 269 Campus Dr. Stanford University School of Medicine Stanford CA USA 2GRECC Palo Alto VA Health Care System 3801 Miranda Ave. Palo Alto CA USA 3University of Washington 1705 NE Pacific St. Seattle WA USA department of Neurology and Neurological Sciences Stanford University School of Medicine Beckman B-002 279 Campus Dr. Stanford CA USA Corresponding author William H Robinson wrobins@ Received 15 Apr 2008 Revisions requested 9 Jun 2008 Revisions received 30 Aug 2008 Accepted 30 Sep 2008 Published 30 Sep 2008 Arthritis Research Therapy 2008 10 R119 doi ar2523 This article is online at http content 10 5 R119 2008 Kidd et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Anti-citrullinated protein antibodies have a diagnostic role in rheumatoid arthritis RA however little is known about their origins and contribution to pathogenesis. Citrullination is the post-translational conversion of arginine to citrulline by peptidyl arginine deiminase and increased citrullination of proteins is observed in the joint tissue in RA and in brain tissue in multiple sclerosis MS . Methods We applied synovial and myelin protein arrays to examine epitope spreading of B cell responses to citrullinated epitopes in both the collagen-induced arthritis CIA model for RA and the .