tailieunhanh - Neuropilin: From Nervous System to Vascular and Tumor Biology

Neuropilin (NRP) and plexin (Plex) that are now known to be semaphorin receptors were initially identified as antigens for monoclonal antibodies (MAbs) that bound to particular neuropiles and plexiform layers of the Xenopus tadpole optic tectum, several years before the discovery of semaphorin. The extracellular segment of the NRP protein is a mosaic of 3 functionally different protein motifs that are thought to be involved in molecular and/or cellular interactions, suggesting that NRP serves in a various cell-cell interaction by binding a variety of molecules. The first identified function of NRP was the cell adhesion activity; Cell reaggregation study using NRP-expressing cell lines revealed that NRP can mediate. | Dominique Bagnard . Neuropilin From NervoUs System to Vascular and Tumor Biology w_ KLUWER ACADEMIC PLENUM PUBLISHERS LANDES BIOSCIENCE Neuropilin From Nervous System to Vascular and Tumor Biology Neuropilin From Nervous System to Vascular and Tumor Biology Edited by Dominique Bagnard . Maỉtre de Conferences Université Louis Pasteur 67084 Strasbourg France email bagnard@ Kluwer Academic Plenum Publishers New York Boston Dordrecht London .