tailieunhanh - Báo cáo y học: "Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients"

Available online Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients. | Available online http content 10 5 R112 Research article Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients Qiong Fu1 2 Xiaoqing Chen1 2 Huijuan Cui1 2 Yanzhi Guo1 Jing Chen1 Nan Shen1 2 and Chunde Bao1 Shanghai Institute of Rheumatology Renji Hospital Shanghai Jiao Tong University School of Medicine Shan Dong Middle Road Shanghai 200001 PR China 2Molecular Rheumatology Laboratory Institute of Health Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine Chong Qing South Road Shanghai 200025 PR China Contributed equally Corresponding author Nan Shen nanshensibs@ Bao baochunde_1678@ Received 28 Feb 2008 Revisions requested 15 Apr 2008 Revisions received 2 Sep 2008 Accepted 15 Sep 2008 Published 15 Sep 2008 Arthritis Research Therapy 2008 10 R112 doi ar2510 This article is online at http content 10 5 R112 2008 Fu et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Systemic lupus erythematosus SLE is a multisystem autoimmune disease with a heterogeneous course and varying degrees of severity and organ damage thus there is increasing interest in identifying biomarkers for SLE. In this study we correlated the combined expression level of multiple interferon-inducible chemokines with disease activity degree of organ damage and clinical features in SLE and we investigated their roles as biomarkers. Methods Peripheral blood cells obtained from 67 patients with SLE patients 20 patients with rheumatoid arthritis RA and 23 healthy donors