tailieunhanh - Báo cáo y học: "Role of hypoxia-inducible factor 1alpha in the integrity of articular cartilage in murine knee joints"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Role of hypoxia-inducible factor 1alpha in the integrity of articular cartilage in murine knee joints. | Available online http content 10 5 R111 Research article Role of hypoxia-inducible factor lalpha in the integrity of articular cartilage in murine knee joints Kolja Gelse1 2 3 David Pfander4 Simon Obier1 Karl X Knaup3 Michael Wiesener3 Friedrich F Hennig2 and Bernd Swoboda1 Open Access Division of Orthopaedic Rheumatology University of Erlangen-Nuremberg Rathsberger StraBe 57 Erlangen 91054 Germany 2Department of Orthopaedic Trauma Surgery University Hospital Erlangen KrankenhausstraBe 12 Erlangen 91054 Germany interdisciplinary Center for Clinical Research University Hospital Erlangen GluckstraBe 6 Erlangen 91054 Germany 4Division of Orthopaedic Rheumatology Hufeland-Clinic Langensalzaer LandstraBe 1 Muehlhausen 99974 Germany Corresponding author Kolja Gelse Received 28 May 2008 Revisions requested 30 Jun 2008 Revisions received 18 Aug 2008 Accepted 12 Sep 2008 Published 1 2 Sep 2008 Arthritis Research Therapy 2008 10 R111 doi 86 ar2508 This article is online at http content 10 5 R111 2008 Gelse et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Chondrocytes have to withstand considerable hypoxic conditions within the avascular articular cartilage. The present study investigated the effects of inhibiting or stabilizing hypoxia-inducible factor HIF -1a by 2-methoxyestradiol or dimethyloxaloylglycine on the progression of osteoarthritis in murine knee joints. Methods 2-Methoxyestradiol was injected six times over a period of 2 weeks into the left knee joint of Balb C mice. Joints were assessed by histochemical and immunohistochemical methods 3 weeks and 12 weeks following the first injection. Dimethyloxaloylglycine an inhibitor .