tailieunhanh - Báo cáo y học: "An important step towards completing the rheumatoid arthritis cycle"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: An important step towards completing the rheumatoid arthritis cycle. | Available online http content 10 5 117 Editorial An important step towards completing the rheumatoid arthritis cycle Walther J van Venrooij and Ger JM Pruijn Department of Biomolecular Chemistry Radboud University Nijmegen NL-6500 HB Nijmegen The Netherlands Corresponding author Walther J van Venrooij Published 19 September 2008 Arthritis Research Therapy 2008 10 117 doi ar2504 This article is online at http content 10 5 117 2008 BioMed Central Ltd See related research article by Zhao et al. http content 10 4 R94 Abstract In the previous issue of Arthritis Research Therapy data are presented showing that circulating immune complexes containing citrullinated fibrin ogen are present in anti-citrullinated protein antibody-positive rheumatoid arthritis patients and that such immune complexes co-localize with complement factor C3 in the rheumatoid synovium. These results corroborate the idea that citrullination is intimately involved in the pathophysiology of rheumatoid arthritis and complete our model the rheumatoid arthritis cycle for the development and chronic nature of this disease. Rheumatoid arthritis RA is a chronic progressive inflammatory autoimmune disease characterized by the presence of several autoantibodies. Among the autoantibodies detected in RA only rheumatoid factor and anti-citrullinated protein peptide antibodies ACPAs are considered clinically useful. Both the measurement of antibodies directed against cyclic citrullinated peptides CCP and rheumatoid factor determinations are commonly used in daily clinical practice. Because of the extreme specificity of ACPAs we and others have previously proposed that these antibodies might be involved in the pathophysiology of RA. Since then experimental evidence supporting several pieces of the RA cycle Figure 1 has been obtained. In the previous issue of Arthritis Research Therapy Zhao and colleagues 1 fill .