tailieunhanh - Báo cáo y học: "Correction: Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Correction: Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus. | Available online http content 10 5 406 Correction Correction Initial clinical trial of epratuzumab humanized anti-CD22 antibody for immunotherapy of systemic lupus erythematosus Thomas Dorner1 Joerg Kaufmann1 William A Wegener2 Nick Teoh2 David M Goldenberg2 3 and Gerd R Burmester1 1 Department of Medicine Rheumatology and Clinical Immunology Charite Hospital Berlin Germany 2Immunomedics Inc. Morris Plains NJ USA 3Center for Molecular Medicine and Immunology Belleville NJ USA Corresponding author Thomas Dorner Published 9 September 2008 Arthritis Research Therapy 2008 10 406 doi ar2499 This article is online at http content 10 5 406 2008 BioMed Central Ltd See related research by Dorner et al. at http content 8 3 R74 Following publication of our article 1 we noticed an error in the stated dose of methotrexate within the section Results in the paragraph Demographics and patient characteristics at study entry . In this paragraph it is stated that two patients were receiving 20 mg day methotrexate. This should read 20 mg week methotrexate. The paragraph should therefore read as follows A total of 14 Caucasian patients 13 females and 1 male 23 to 53 years old median age 40 years were enrolled. At study entry the patients had been initially diagnosed with SLE 1 to 19 years median 10 years earlier and were receiving corticosteroids n 13 1 to 12mg day prednisolone plus immunosuppressives n 11 including 50 to 200 mg day azathioprine n 9 20 mg week methotrexate n 2 2 g day mycophenalate mofetil n 1 and antimalarials n 6 200 to 600 mg day hydroxychloroquine . All patients had positive ANA at study entry titers of 80 1 to 5 120 1 and 5 patients 36 had positive anti-dsDNA antibody levels 10U ml . Ten patients 71 had ESR values that were elevated 15 mm h and 4 patients 29 had raised CRP levels mg dl while only 3 patients 21 had C3 levels that were borderline low or .