tailieunhanh - Báo cáo y học: "Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab. | Available online http content 10 5 R105 Research article Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab Sanna Rosengren1 Nathan Wei2 Kenneth C Kalunian1 Nathan J Zvaifler1 Arthur Kavanaugh1 and David L Boyle1 1 Division of Rheumatology Allergy and Immunology University of California at San Diego School of Medicine 9500 Gilman Drive La Jolla CA 92093 USA _ 2Arthritis and Osteoporosis Center of Maryland 71 Thomas Johnson Drive Frederick MD 21702 USA Corresponding author David L Boyle dboyle@ Received 2 Jun 2008 Revisions requested 7 Jul 2008 Revisions received 14 Aug 2008 Accepted 1 Sep 2008 Published 1 Sep 2008 Arthritis Research Therapy 2008 10 R105 doi ar2497 This article is online at http content 10 5 R105 2008 Rosengren et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The purpose of this study was to quantitatively evaluate the contribution of synovial lymphoid aggregates to autoantibody rheumatoid factor RF and anti-cyclic citrullinated peptide anti-CCP and total immunoglobulin IgG and IgM production in rheumatoid arthritis RA patients and the effect thereon of the B-cell-depleting antibody rituximab in the ARISE Assessment of Rituximab s Immunomodulatory Synovial Effects trial. Methods Autoantibodies as well as total IgM and IgG were quantified by enzyme-linked immunosorbent assay in extracts of synovial tissues and matched serum from patients with RA or osteoarthritis OA . Synovial biopsies and serum were obtained at baseline and 8 weeks following rituximab therapy in 14 RA patients. A synovial serum index SSI was calculated as the ratio of synovial .