tailieunhanh - Báo cáo y học: "Colony variability under the spotlight in animal models of arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Colony variability under the spotlight in animal models of arthritis. | Available online http content 11 2 110 Editorial Colony variability under the spotlight in animal models of arthritis John H Robinson Musculoskeletal Research Group Institute of Cellular Medicine Newcastle University Framlington Place Newcastle upon Tyne NE2 4HH UK Corresponding author John H Robinson Published 30 April 2009 Arthritis Research Therapy 2009 11 110 doi ar2653 This article is online at http content 11 2 110 2009 BioMed Central Ltd See related research article by Farkas et al. http content 11 1 R21 Abstract A recent article by Farkas and colleagues published in Arthritis Research Therapy is from the laboratory of Dr Tibor Glant and his research team in Chicago who have investigated in considerable depth the immunopathology of experimental arthritis induced by the major cartilage component proteoglycan aggrecan in an animal model that mimics many features of human rheumatoid arthritis and ankylosing spondylitis. This present report takes our understanding a significant step forward by questioning whether genetic drift in distinct colonies of the same inbred strains of mice has an impact on the parity between data published by different laboratories. In the previous issue of Arthritis Research Therapy Farkas and colleagues 1 compare a large number of colonies of the widely used BALB c inbred mouse strain the authors communicate largely good news that substrains vary only modestly in phenotype and the incidence and severity of arthritis. Confidence in data derived from studying the mechanisms of immunopathology in patients with rheumatoid arthritis RA or ankylosing spondylitis is undermined by many variables. One is the genetic diversity of patients in a single cohort or diversity between cohorts studied in different laboratories. Despite a strong association between the expression of certain HLA DR alleles and RA many additional major histocompatibility .