tailieunhanh - Báo cáo y học: "Mechanisms of new bone formation in spondyloarthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Mechanisms of new bone formation in spondyloarthritis. | Available online http content 11 2 221 Review Progress in spondylarthritis Mechanisms of new bone formation in spondyloarthritis Rik JU Lories Frank P Luyten and Kurt de Vlam Laboratory for Skeletal Development and Joint Disorders Division of Rheumatology Department of Musculoskeletal Sciences Katholieke Universiteit Leuven Belgium Corresponding author Rik Lories Published 27 April 2009 This article is online at http content 11 2 221 2009 BioMed Central Ltd Arthritis Research Therapy 2009 11 221 doi ar2642 Abstract Targeted therapies that neutralize tumour necrosis factor are often able to control the signs and symptoms of spondyloarthritis. However recent animal model data and clinical observations indicate that control of inflammation may not be sufficient to impede disease progression toward ankylosis in these patients. Bone morphogenetic proteins and WNTs wingless-type like are likely to play an important role in ankylosis and could be therapeutic targets. The relationship between inflammation and new bone formation is still unclear. This review summarizes progress made in our understanding of ankylosis and offers an alternative view of the relationship between inflammation and ankylosis. Introduction The spondyloarthritides SpAs are a group of chronic inflammatory diseases of the skeleton and associated soft tissues. Different diagnostic entities that share clinical pathological and genetic characteristics are integrated into this disease concept. These include ankylosing spondylitis AS psoriatic arthritis PsA inflammatory bowel disease-associated arthritis reactive arthritis juvenile SpA and undifferentiated SpA 1 . The prevalence and burden of SpAs in particular AS and PsA are at least as high as those of rheumatoid arthritis RA 1-3 . Sacroiliitis and spinal inflammation as well as peripheral arthritis and enthesitis often with a nonsymmetrical distribution are typical clinical .