tailieunhanh - Báo cáo y học: "5HT2A polymorphism His452Tyr in a German Caucasian systemic sclerosis population - authors’ response"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: 5HT2A polymorphism His452Tyr in a German Caucasian systemic sclerosis population - authors’ response. | Available online http content 11 2 404 Letter 5HT2A polymorphism His452Tyr in a German Caucasian systemic sclerosis population - authors response Lorenzo Beretta and Raffaella Scorza Referral Center for Systemic Autoimmune Diseases IRCCS Fondazione Policlinico-Mangiagalli-Regina Elena and University of Milan Via Pace 20122 Milan Italy Corresponding author Raffaella Scorza Published 26 March 2009 Arthritis Research Therapy 2009 11 404 doi ar2635 This article is online at http content 11 2 404 2009 BioMed Central Ltd See related research by Beretta et al. http content 10 5 R103 and related letter by Kirsten et al. http content 11 2 403 The variance of results between our recent article 1 and the replication study by Kirsten and colleagues 2 in German patients may prompt the reader to ask the simple question what conclusion can be drawn from these contradictory results One possible answer is that one of the two studies is wrong and all the clues would indicate the first report as the one describing a spurious finding. This is consistent with a general overestimate of the role of a gene in the first association study of it 3 and indeed we have always been aware of the possibility of false positive findings. Hence we provided the reader a mean for example the false probability report probability with which to gauge the strength of the association and the chance of having described a spurious result 1 . A second possible answer is that the variance of results stems from methodological differences between the two studies. It has been argued that replication studies should be viewed as tools to uncover heterogeneity rather than tools to test the hypothesis generated by the initial association 3 and in a more extreme view the relevance of replication has been questioned 4 . Our and Kirsten and colleagues studies are heterogeneous with regard to many