tailieunhanh - Báo cáo y học: "Increased expression of FcγRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Increased expression of FcγRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus. | Available online http content 11 1 R6 Research article Increased expression of FcyRI CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus Yi Li1 Pui Y Lee1 2 Eric S Sobel1 Sonali Narain1 Minoru Satoh1 Mark S Segal2 Westley H Reeves1 and Hanno B Richards1 3 Division of Rheumatology Clinical Immunology University of Florida 1600 SW Archer Road Gainesville FL 32610-0221 USA 2Division of Nephrology Hypertension and Transplantation Department of Medicine University of Florida 1600 SW Archer Road Gainesville FL 32610-0221 USA 3Schering-Plough Corporation Kenilworth NJ 07033-0530 USA Corresponding author Yi Li liyi@ Received 29 Aug 2008 Revisions requested 24 Oct 2008 Revisions received 21 Nov 2008 Accepted 14 Jan 2009 Published 14 Jan 2009 Arthritis Research Therapy 2009 11 R6 doi 1 ar2590 This article is online at http content 11 1 R6 2009 Li et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The high-affinity receptor for IgG Fcy CD64 is critical for the development of lupus nephritis LN . Cross-linking Fc receptor on recruited monocytes by IgG-containing immune complexes is a key step in immune-complex-mediated nephritis in systemic lupus erythematosus SLE . The goal of this study was to determine whether expression of Fc receptor FcyR I on circulating monocytes is associated with systemic inflammation and renal disease in SLE patients. Methods We studied 205 SLE patients 132 with LN and 73 without LN along with 74 healthy control individuals. Surface expression of CD14 monocytes FcyRI CD64 FcyRII CD32 and FcyRIII CD16 was evaluated by flow cytometry. Monocyte function was assessed by .