tailieunhanh - Báo cáo y học: "Identification of possible candidate genes regulating Sjögren's syndrome-associated autoimmunity: a potential role for TNFSF4 in autoimmune exocrinopathy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of possible candidate genes regulating Sjögren's syndrome-associated autoimmunity: a potential role for TNFSF4 in autoimmune exocrinopathy. | Available online http content 10 6 R137 Research article Identification of possible candidate genes regulating Sjogren s syndrome-associated autoimmunity a potential role for TNFSF4 in autoimmune exocrinopathy Cuong Q Nguyen1 Janet G Cornelius2 Lauren Cooper1 Jonathan Neff1 Joann Tao1 Byung Ha Lee1 and Ammon B Peck1 2 3 Department of Oral Biology University of Florida 1600 SW Archer Road Gainesville FL 32610 USA department of Pathology Immunology Laboratory Medicine University of Florida 1600 SW Archer Road Gainesville FL 32610 USA 3Center for Orphan Autoimmune Disorders College of Dentistry University of Florida 1600 SW Archer Road Gainesville FL 32610 USA Corresponding author Cuong Q Nguyen Nguyen@ Received 26 Aug 2008 Revisions requested 23 Oct 2008 Revisions received 27 Oct 2008 Accepted 25 Nov 2008 Published 25 Nov 2008 Arthritis Research Therapy 2008 10 R137 doi 86 ar2560 This article is online at http content 10 6 R137 2008 Nguyen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Sjogren syndrome SjS is a systemic autoimmune disease in which an immunological attack primarily against the salivary and lacrimal glands results in the loss of acinar cell tissue and function leading to stomatitis sicca and keratoconjunctivitis sicca. In recent years two genetic regions one on chromosome 1 designated autoimmune exocrinopathy 2 or Aec2 and the second on chromosome 3 designated autoimmune exocrinopathy 1 or AecT derived from nonobese diabetic NOD mice have been shown to be necessary and sufficient to replicate SjS-like disease in nonsusceptible C57BL 6 mice. Methods Starting with the SjS-susceptible C57BL 6-derived .