tailieunhanh - Báo cáo y học: "Vitamin D or hormone D deficiency in autoimmune rheumatic diseases, including undifferentiated connective tissue disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Vitamin D or hormone D deficiency in autoimmune rheumatic diseases, including undifferentiated connective tissue disease. | Available online http content 10 6 123 Editorial Vitamin D or hormone D deficiency in autoimmune rheumatic diseases including undifferentiated connective tissue disease Maurizio Cutolo Research Laboratory and Acadenic Clinical Unit of Rheumatology department of Internal Medicine University of Genova Viale Bnedetto XV 6 161 32 Genova Italy Corresponding author Maurizio Cutolo mcutolo@ Published 2 December 2008 Arthritis Research Therapy 2008 10 123 doi ar2552 This article is online at http content 10 6 123 2008 BioMed Central Ltd See related research article by Zold et al. http content 10 5 R123 Abstract Epidemiological evidence indicates a significant association between vitamin D deficiency and an increased incidence of autoimmune diseases. The presence of vitamin D receptors in the cells of the immune system and the fact that several of these cells produce the vitamin D hormone suggested that vitamin D could have immunoregulatory properties and now potent immuno-mudulatory activities on dendritic cells Th1 and Th17 cells as well as B cells have been confirmed. Patients with undifferentiated connective tissue disease also show vitamin D deficiency and interestingly patients who progress into connective tissue diseases have lower vitamin D levels than those who remain in the undifferentiated connective tissue disease stage. Vitamin D deficiency and autoimmune diseases The recent study by Zold and colleagues 1 reports that a seasonal variance in levels of 25 OH D3 was identified in patients with undifferentiated connective tissue disease UCTD and showed that these levels were in any case significantly lower than in controls during the corresponding seasons. The results showed also that more severe vitamin D deficiency in UCTD patients may play a role in the subsequent progress into well-defined connective tissue diseases CTDs . Epidemiological evidence indicates a significant .