tailieunhanh - Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology

Of the 600+ known proteases identified to date in mammals, a significant percentage is involved or implicated in pathogenic and cancer processes. The dipeptidyl peptidase IV (DPIV) gene family, comprising four enzyme members [DPIV (EC ), fibroblast activation protein, DP8 and DP9] and two nonenzyme members [DP6 (DPL1) and DP10 (DPL2)], are inter-esting in this regard because of their multiple diverse functions, | REVIEW ARTICLE The dipeptidyl peptidase IV family in cancer and cell biology Denise M. T. Yu1 Tsun-Wen Yao1 Sumaiya Chowdhury1 Naveed A. Nadvi1 2 Brenna Osborne1 W. Bret Church2 Geoffrey W. McCaughan1 and Mark D. Gorrell1 1 . Morrow Gastroenterology and Liver Centre RoyalPrince Alfred Hospital Centenary Institute and Sydney MedicalSchool University of Sydney Australia 2 PharmaceuticalChemistry Faculty of Pharmacy University of Sydney Australia Keywords cancer dipeptidyl peptidase distribution enzyme extracellular matrix immune function liver fibrosis structure Correspondence M. D. Gorrell Molecular Hepatology Centenary Institute Locked Bag No. 6 Newtown NSW 2042 Australia Fax 61 2 95656101 Tel 61 2 95656156 E-mail Received 23 October 2009 revised 25 November 2009 accepted 30 November 2009 Of the 600 known proteases identified to date in mammals a significant percentage is involved or implicated in pathogenic and cancer processes. The dipeptidyl peptidase IV DPIV gene family comprising four enzyme members DPIV EC fibroblast activation protein DP8 and DP9 and two nonenzyme members DP6 DPL1 and DP10 DPL2 are interesting in this regard because of their multiple diverse functions varying patterns of distribution localization and subtle but significant differences in structure substrate recognition. In addition their engagement in cell biological processes involves both enzymatic and nonenzymatic capabilities. This article examines in detail our current understanding of the biological involvement of this unique enzyme family and their overall potential as therapeutic targets. doi Introduction Proteases are heavily involved in specialized biological functions and thus often play important roles in pathogenesis. The dipeptidyl peptidase IV DPIV CD26 gene family has attracted ongoing pharmaceutical interest in the areas of metabolic disorders and cancer. Four of its members - DPIV EC .

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