tailieunhanh - Báo cáo khoa học: RMI1 deficiency in mice protects from diet and genetic-induced obesity

The aim of this study is to discover and characterize novel energy homeo-stasis-related molecules. We screened stock mouse embryonic stem cells established using the exchangeable gene trap method, and examined the effects of deficiency of the target gene on diet and genetic-induced obesity. | RMI1 deficiency in mice protects from diet and genetic-induced obesity 1 2 3 2 3 Akira Suwa Masayasu Yoshino Chihiro Yamazaki Masanori Naitou Rie Fujikawa3 Shun-ichiro Matsumoto2 Takeshi Kurama1 Teruhiko Shimokawa1 and Ichiro Aramori2 1 Pharmacology Research Labs Astellas Pharma Inc. Tsukuba Ibaraki Japan 2 Molecular Medicine Labs Astellas Pharma Inc. Tsukuba Ibaraki Japan 3 Trans Genic Inc. Chuo-ku Tokyo Japan Keywords E2F energy homeostasis gene trap high-fat diet obesity RMI1 Correspondence A. Suwa Department of Metabolic Diseases Pharmacology Research Labs Drug Discovery Research Astellas Pharma Inc. 21 Miyukigaoka Tsukuba-shi Ibaraki 305-8585 Japan Fax 81 29 852 5391 Tel 81 29 863 6417 E-mail Received 2 September 2009 revised 19 November 2009 accepted 24 November 2009 doi The aim of this study is to discover and characterize novel energy homeostasis-related molecules. We screened stock mouse embryonic stem cells established using the exchangeable gene trap method and examined the effects of deficiency of the target gene on diet and genetic-induced obesity. The mutant strain 0283 which has an insertion at the recQ-mediated genome instability 1 RMI1 locus possesses a number of striking features that allow it to resist metabolic abnormalities. Reduced RMI1 expression lower fasting-blood glucose and a reduced body weight normal diet were observed in the mutant mice. When fed a high-fat diet the mutant mice were resistant to obesity and also showed improved glucose intolerance and reduced abdominal fat tissue mass and food intake. In addition the mutants were also resistant to obesity induced by the lethal yellow agouti Ay gene. Endogenous RMI1 genes were found to be up-regulated in the liver and adipose tissue of KK-Ay mice. RMI1 is a component of the Bloom s syndrome gene helicase complex that maintains genome integrity and activates cell-cycle checkpoint machinery. Interestingly diet-induced expression

• Báo cáo khoa học
• Scientific reports
• scientific research
• biochemistry
• Hydrogenobacter
• enzymatic
• biological activities
• Seagrass species
• Positive biological activities
• Coastal area of Vietnam
• Vietnam Sea
• Summary of Chemistry Doctoral Thesis
• Chemistry Doctoral Thesis
• Biological activities of callicarpa candicans
• Biological activities of callicarpa macrophylla
• Chemistry of natural compounds
• Summary of the Doctoral thesis
• Study on chemical constituents
• Biological activities of litsea glutinosa
• Lepisanthes rubiginosa
• Potential biological activities
• Biological activity
• Medicinal plants
• Biological screening
• Antitumor activities
• Mentha pulegium L
• Summary of biological doctoral thesis
• Research on mangrove vegetation
• Bological activities
• Xuan Thuy National Park
• Propose sustainable usage
• Typical mangrove vegetation communities
• Anti cancer
• Anti inflammatory
• Mallotus species
• Phytochemical and pharmacological activities
• Gallic acid
• Agricultural science
• Biological chemical
• Antioxidant activities
• Biological and chemical changes
• Acetic acid productivity
• Fermented tea
• Report medicine
• traditional medicine
• breast cancer
• environmental medicine
• Medical Research
• chemical reaction
• Công nghệ hóa
• Chemical constituents
• Alpinia conchigera griff
• Thành phần hóa học
• Hoạt tính sinh học
• Sedum acre
• Antiproliferative activity
• Goldmoss stonecrop
• Fetal bovine serum
• Vietnam Journal of Science and Technology
• Chemical constituents and biological activities
• Alpinia kwangsiensis collected in Vietnam
• Methanol extract of Alpinia kwangsiensis roots
• Staphylococcus aureus and Bacillus subtilis
• Tạp chí Phát triển Khoa học và Công nghệ
• Screening for some biological activities of Cultured cordyceps neovolkiana
• Cultured cordyceps neovolkiana
• C
• neovolkiana extracts
• Chemical constituents of Tacca vietnmensis and Tacca chantrierispecies
• Biological activities of Tacca vietnmensis
• Tacca chantrierispecies growing in Vietnam
• Find out bioactive compoundse
• Structural characteristics of fucoidans extracted
• Biological activities of fucoidans extracted
• Selected vietnamese brown seaweeds
• Several brown algae
• Antibacterial activity
• Anticancer activity
• Textile dyeing
• Natural colorant production
• BMC Chemistry
• Oxazole derivatives
• Heterocyclic systems
• Therapeutic potentials
• Anticancer activities
• Thiourea derivatives
• Exhibited biological activities
• Benzenesulfonamide derivatives
• Amberlyst A 15
• Various synthetic methods
• Indole and imidazole rings
• Synthetic approaches and biological activities
• Substituted indolylimidazole derivatives
• Oil properties DEH enzyme maize proline
• Influence of exogenous compounds
• Exogenous compounds
• Maize crop residue
• Salt affected soil
• Natural science
• Pseuderanthemum palatiferum
• Tyrosinase inhibitory activity
• Phytochemical constituents
• n hexane fractions
• Luận án Tiến sĩ
• Summary of Doctoral thesis in Chemistry
• Chemical compositions
• Paramignya trimera
• Organic chemistry
• Luận án Tiến sĩ Hóa học
• Antidesma species growing
• Fokienia hodginsii
• Dacrycarpus imbricatus