tailieunhanh - báo cáo khoa học: "Autonomous growth potential of leukemia blast cells is associated with poor prognosis in human acute leukemias"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Autonomous growth potential of leukemia blast cells is associated with poor prognosis in human acute leukemias | Journal of Hematology Oncology BioMed Central Research Autonomous growth potential of leukemia blast cells is associated with poor prognosis in human acute leukemias Ying Yan 1 2 Eric A Wieman1 2 Xiuqin Guan2 Ann A Jakubowski3 Peter G Steinherz3 and Richard J O Reilly3 Open Access Address rfhe Saint Luke s Cancer Institute 4321 Washington Suite 4000 Kansas City Missouri 64111 USA 2School of Medicine University Missouri-Kansas City Holmes Road Kansas City Missouri 64108 USA and 3Bone Marrow Transplantation Service and the Department of Pediatrics Memorial Sloan Kettering Cancer Center New York New York USA Email Ying Yan - yany@ Eric A Wieman - wiemane@ Xiuqin Guan - guanxiu@ Ann A Jakubowski - jakubowa@ Peter G Steinherz - steinhep@ Richard J O Reilly - oreillyr@ Corresponding author Published 29 December 2009 Received 29 September 2009 Accepted 29 December 2009 Journal of Hematology Oncology 2009 2 51 doi 1756-8722-2-51 r This article is available from http content 2 1 51 2009 Yan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We have described a severe combined immunodeficiency SCID mouse model that permits the subcutaneous growth of primary human acute leukemia blast cells into a measurable subcutaneous nodule which may be followed by the development of disseminated disease. Utilizing the SCID mouse model we examined the growth potential of leukemic blasts from 133 patients with acute leukemia 67 acute lymphoblastic leukemia ALL and 66 acute myeloid leukemia AML in the animals after subcutaneous inoculation without conditioning treatment. The blasts displayed three distinct growth patterns aggressive indolent or no tumor growth .