tailieunhanh - Báo cáo khoa học: The transcriptome of the colonial marine hydroid Hydractinia echinata

CXXC finger protein 1 (Cfp1), encoded by theCXXC1gene, is a compo-nent of the euchromatic Setd1A histone H3K4 methyltransferase complex, and is a critical regulator of histone methylation, cytosine methylation, cel-lular differentiation, and vertebrate development. | ỊFEBS Journal The transcriptome of the colonial marine hydroid Hydractinia echinata Jorge Soza-Ried1 Agnes Hotz-Wagenblatt2 Karl-Heinz Glatting2 Coral del Val2 3 Kurt Fellenberg1 4 Hans R. Bode5 Uri Frank6 Jorg D. Hoheisel1 and Marcus Frohme1 7 1 Division of FunctionalGenome Analysis Deutsches Krebsforschungszentrum DKFZ Heidelberg Germany 2 Division of Molecular Biophysics Deutsches Krebsforschungszentrum DKFZ Heidelberg Germany 3 Department of Computer Science and ArtificialIntelligence . Informatics Universidad de Granada Spain 4 Bioanalytics Group TechnicalUniversity Munich Freising Germany 5 DevelopmentalBiology Center and Developmentaland CellBiology Department University of California at Irvine CA USA 6 Schoolof NaturalSciences and Martin Ryan Marine Science Institute NationalUniversity of Ireland Galway Ireland 7 Molecular Biology and FunctionalGenome Analysis University of Applied Sciences Wildau Germany Keywords Cnidaria database EST Hydractinia transcriptome Correspondence J. Soza-Ried Division of Functional Genome Analysis Deutsches Krebsforschungszentrum DKFZ Im Neuenheimer Feld 580 69121 Heidelberg Germany Fax 49 6221 424687 Tel 49 6221 424678 E-mail Received 11 August 2009 revised 1 November 2009 accepted 3 November 2009 doi An increasing amount of expressed sequence tag EST and genomic data predominantly for the cnidarians Acropora Hydra and Nematostella reveals that cnidarians have a high genomic complexity despite being one of the morphologically simplest multicellular animals. Considering the diversity of cnidarians we performed an EST project on the hydroid Hydractinia echinata to contribute towards a broader coverage of this phylum. After random sequencing of almost 9000 clones EST characterization revealed a broad diversity in gene content. Corroborating observations in other cnidarians Hydractinia sequences exhibited a higher sequence similarity to vertebrates than to .