tailieunhanh - Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor

A common physiological response of organisms to environmental stresses is the increase in expression of heat shock proteins (Hsps). In insects, this process has been widely examined for heat stress, but the response to cold stress has been far less studied. | ỊFEBS Journal REVIEW ARTICLE Calmodulin-mediated regulation of the epidermal growth factor receptor Pablo Sanchez-Gonzalez Karim Jellali and Antonio Villalobo Institute de Investigaciones Biomedicas Consejo Superior de Investigaciones Cientificas Madrid Spain Keywords calcium calmodulin capacitative calcium entry channels epidermalgrowth factor receptor ErbB receptors G protein-coupled receptor membranes metalloprotease tyrosine kinase Correspondence A. Villalobo Instituto de Investigaciones Biomedicas Consejo Superior de Investigaciones Cientificas Arturo Duperier 4 E-28029 Madrid Spain Fax 34 91 585 4401 Tel 34 91 585 4424 E-mail Present address Centre of Biotechnology of Sfax Sfax Tunisia In this review we first describe the mechanisms by which the epidermal growth factor receptor generates a Ca2 signal and subsequently we compile the available experimental evidence regarding the role that the Ca2 calmodulin complex formed after the rise in cytosolic free Ca2 concentration exerts on the receptor. We focus not only on the indirect action that Ca2 calmodulin exerts on the epidermal growth factor receptor as a result of the activation of distinct calmodulin-dependent kinases but also and more extensively on the direct interaction of Ca2 calmodu-lin with the receptor. We also describe several mechanistic models that could account for the Ca2 calmodulin-mediated regulation of epidermal growth factor receptor activity. The control exerted by calmodulin on distinct epidermal growth factor receptor-mediated cellular functions is also discussed. Finally the phosphorylation of this Ca2 sensor by the epidermal growth factor receptor is highlighted. Received 20 August 2009 revised 30 September 2009 accepted 29 October 2009 doi Introduction The calcium ion is enormously important for regulating multiple cellular functions. Its role as a second messenger based on its low free cytosolic concentration under basal .

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