tailieunhanh - Bài báo cáo cáo khoa học - Retraction: Human telomeric G-quadruplex

Thermodynamic and kinetic studies complement high-resolution structures of G-quadruplexes. Such studies are essential for a thorough understanding of the mechanisms that govern quadruplex folding and conformational changes in quadruplexes. | MINIREVIEW Retraction Human telomeric G-quadruplex targeting with small molecules Amit Arora Niti Kumar Tani Agarwal and Souvik Maiti Proteomics and StructuralBiology Unit Institute of Genomics and Integrative Biology Delhi India Retraction The following review from FEBS Journal Human telomeric G-quadruplex targeting with small molecules by Amit Arora Niti Kumar Tani Agarwal and Souvik Maiti published online on 27th November 2009 in Wiley InterScience has been retracted by agreement between the authors the journal Editor-in-Chief Professor Richard Perham and Blackwell Publishing Ltd. The retraction has been agreed due to overlap between this review and the following reviews Published in Organic Biomolecular Chemistry A hitchhiker s guide to G-quadruplex ligands by David Monchaud and Marie-Paule Teulade-Fichou. Volume 6 Issue 4 2008 pages 627-636. Published in BioChimie Targeting telomeres and telomerase by Anne De Cian Laurent Lacroix Celine Douarre Nassima Temime-Smaali Chantal Trentesaux Jean-Francois Riou and Jean-Louis Mergny. Volume 90 Issue 1 2008 pages 131-155. Keywords alkaloids anticancer agent click chemistry ethidium derivative G-quadruplex human telomere metallo-organic complex N-methylated ligands proto-oncogenes telomerase Correspondence S. Maiti Proteomics and Structural Biology Unit Institute of Genomics and Integrative Biology CSIR MallRoad Delhi 110 007 India Fax 91 11 2766 7471 Tel 91 11 2766 6156 E-mail souvik@ Received 25 June 2009 revised 1 September 2009 accepted 28 September 2009 doi Over the past few decades numerous small molecules have been designed to specifically and selectively target the unusual secondary structure in DNA called the G-quadruplex. Because these ligands have been shown to selectively inhibit the growth of cancer cells they have become a central focus for the development of novel anticancer agents. However there are many challenges which demand .