tailieunhanh - báo cáo khoa học: "Topoisomerase II alpha gene copy loss has adverse prognostic significance in ERBB2-amplified breast cancer: a retrospective study of paraffin-embedded tumor specimens and medical charts"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Topoisomerase II alpha gene copy loss has adverse prognostic significance in ERBB2-amplified breast cancer: a retrospective study of paraffin-embedded tumor specimens and medical charts | BioMed Central Journal of Hematology Oncology Open Access Topoisomerase II alpha gene copy loss has adverse prognostic significance in ERBB2-amplified breast cancer a retrospective study of paraffin-embedded tumor specimens and medical charts Lydia Usha 1 Bita Tabesh1 Larry E Morrison2 Ruta D Rao1 Kris Jacobson2 April Zhu3 Sanjib Basu4 and John S Coon5 Address 1Division of Hematology and Oncology Department of Medicine Rush University Chicago Illinois 60612 USA 2Abbott Molecular Inc. Des Plaines Illinois USA 3Midwest Palliative and Hospice Care Center Glenview Illinois USA 4Division of Statistics Northern Illinois University De Kalb Illinois USA and 5Department of Pathology Rush University Chicago Illinois 60612 USA Email Lydia Usha - lydia_usha@ BitaTabesh - bitatabesh@ Larry E Morrison - Ruta D Rao - ruta_rao@ Kris Jacobson - April Zhu - azhu@ Sanjib Basu - sanjib_basu@ John S Coon - john_coon@ Corresponding author Published 14 August 2008 Received 16 June 2008 Journal of Hematology Oncology 2008 1 12 doi l756-8722-l-l2 Accepted 14 August 2008 This article is available from http content l l l2 2008 Usha et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Amplification of the ERBB2 Her-2 neu oncogene which occurs in approximately 25 of breast carcinomas is a known negative prognostic factor. Available data indicate that a variable number of nearby genes on chromosome l7q may be co-amplified or deleted forming a continuous amplicon of variable size. In approximately 25 of these patients the amplicon extends to the gene for topoisomerase II alpha TOP2A a target for .