tailieunhanh - báo cáo khoa học: "Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways | BioMed Central Journal of Hematology Oncology Open Access Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways Quanyi Lu1 2 Xianghua Lin1 Jean Feng1 Xiangmin Zhao1 Ruth Gallagher1 Marietta Y Lee3 Jen-Wei Chiao1 and Delong Liu 1 Address 1Division of Hematology Oncology New York Medical College Valhalla NY 10595 USA 2Department of Hematology Zhongshan Hospital of Xiamen University Xiamen Fujian Province PR China and 3Department of Biochemistry and Molecular Biology New York Medical College Valhalla NY 10595 USA Email Quanyi Lu - Luquanyi@ Xianghua Lin - linxianghua2006@ Jean Feng - Jingyang_feng@ Xiangmin Zhao - Xiangmin_zhao@ Ruth Gallagher - Ruth_gallagher@ Marietta Y Lee - Marietta_lee@ Jen-Wei Chiao - jen-wei_chiao@ Delong Liu - delong_liu@ Corresponding author Published 9 June 2008 Received 26 March 2008 Journal of Hematology Oncology 2008 1 6 doi l 756-8722-1 -6 Accepted 9 June 2008 This article is available from http content 1 1 6 2008 Lu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Histone deacetylase HDAC inhibitors are a new class of chemotherapeutic agents. Our laboratory has recently reported that phenylhexyl isothiocyanate PHI a synthetic isothiocyanate is an inhibitor of HDAC. In this study we examined whether PHI is a hypomethylating agent and its effects on myeloma cells. RPMI8226 a myeloma cell line was treated with PHI. PHI inhibited the proliferation of the myeloma cells and induced apoptosis in a .