tailieunhanh - báo cáo khoa học: "Effect of Ras Inhibition in Hematopoiesis and BCR/ABL Leukemogenesis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Effect of Ras Inhibition in Hematopoiesis and BCR/ABL Leukemogenesis | BioMed Central Journal of Hematology Oncology Research Effect of Ras Inhibition in Hematopoiesis and BCR ABL Leukemogenesis Karina J Baum1 2 and Ruibao Ren 1 Open Access Address 1Rosenstiel Basic Medical Sciences Research Center Department of Biology Brandeis University Waltham MA 02454 USA and 2Current address College of General Studies Boston University 871 Commonwealth Avenue Boston MA 02215 USA Email Karina J Baum - karibaum@ Ruibao Ren - ren@ Corresponding author Published 5 June 2008 Received 20 May 2008 Journal of Hematology Oncology 2008 1 5 doi 1756-8722-1 -5 Accepted 5 June 2008 This article is available from http content 1 1 5 2008 Baum and Ren licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Ras small GTPases are activated in many hematopoietic growth factor signaling and in hematological malignancies but their role in hematopoiesis and leukemogenesis is not completely known. Here we examined the effect of Ras inhibition by a dominant negative mutant of Ras NI7 H-Ras in adult hematopoiesis and in BCR ABL leukemogenesis using the mouse bone marrow transduction and transplantation approach. We found that N17 H-Ras expression suppressed Band T-lymphopoiesis and erythropoiesis. Interestingly N17 H-Ras did not suppress myelopoiesis in the bone marrow yet it greatly attenuated BCR ABL-induced chronic myelogenous leukemia CML -like myeloproliferative disease. Most BCR ABL N17 H-Ras mice eventually developed pro-B lymphoblastic leukemia lymphoma B-ALL . These results suggest that Ras activation is essential for the development of lymphoid and erythroid cells but not myeloid cells and that .