tailieunhanh - báo cáo khoa học: "CyberKnife for hilar lung tumors: report of clinical response and toxicity"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:CyberKnife for hilar lung tumors: report of clinical response and toxicity | Unger et al. Journal of Hematology Oncology 2010 3 39 http content 3 1 39 JOURNAL OF HEMATOLOGY ONCOLOGY SHORT REPORT Open Access CyberKnife for hilar lung tumors report of clinical response and toxicity 1 1 I- -X 1 - - 1 X - X 1 4 2 Keith Unger Andrew Ju Eric Oermann Simeng Suy Xia Yu Saloomeh Vahdat Deepa Subramaniam 11 13 1 K William Harter Sean P Collins Anatoly Dritschilo Eric Anderson Brian T Collins Abstract Objective To report clinical efficacy and toxicity of fractionated CyberKnife radiosurgery for the treatment of hilar lung tumors. Methods Patients presenting with primary and metastatic hilar lung tumors treated using the CyberKnife system with Synchrony fiducial tracking technology were retrospectively reviewed. Hilar location was defined as abutting or invading a mainstem bronchus. Fiducial markers were implanted by conventional bronchoscopy within or adjacent to tumors to serve as targeting references. A prescribed dose of 30 to 40 Gy to the gross tumor volume GTV was delivered in 5 fractions. Clinical examination and PET CT imaging were performed at 3 to 6-month follow-up intervals. Results Twenty patients were accrued over a 4 year period. Three had primary hilar lung tumors and 17 had hilar lung metastases. The median GTV was 73 cc range 23-324 cc . The median dose to the GTV was 35 Gy range 30 - 40 Gy delivered in 5 fractions over 5 to 8 days median 6 days . The resulting mean maximum point doses delivered to the esophagus and mainstem bronchus were 25 Gy range 11-39 Gy and 42 Gy range 30 - 49 Gy respectively. Of the 17 evaluable patients with 3 - 6 month follow-up 4 patients had a partial response and 13 patients had stable disease. AAT t a median follow-up of 10 months the 1-year Kaplan-Meier local control and overall survival estimates were 63 and 54 respectively. Toxicities included one patient experiencing grade II radiation esophagitis and one patient experiencing grade III radiation pneumonitis. One patient with gross .