tailieunhanh - báo cáo khoa học: "Epigenetic modifications as key regulators of Waldenstrom’s Macroglobulinemia biology"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Epigenetic modifications as key regulators of Waldenstrom’s Macroglobulinemia biology | Sacco et al. Journal of Hematology Oncology 2010 3 38 http content 3 1 38 JOURNAL OF HEMATOLOGY ONCOLOGY REVIEW Open Access Epigenetic modifications as key regulators of Waldenstrom s Macroglobulinemia biology Antonio Sacco Ghayas C Issa Yong Zhang Yang Liu Patricia Maiso Irene M Ghobrial Aldo M Roccaro Abstract Waldenstrom s Macroglobulinemia is a low-grade B-cell lymphoma characterized by the presence of lymphoplas-macytic cells in the bone marrow and a monoclonal immunoglobulin M in the circulation. Recent evidences support the hypothesis that epigenetic modifications lead to Waldesntrom cell proliferation and therefore play a crucial role in the pathogenesis of this disease. Indeed while cytogenetic and gene expression analysis have demonstrated minimal changes microRNA aberrations and modification in the histone acetylation status of primary Waldenstrom Macroglobulinemia tumor cells have been described. These findings provide a better understanding of the underlying molecular changes that lead to the initiation and progression of this disease. Introduction First introduced by . Waddington in 1939 to name the causal interactions between genes and their products which bring the phenotype into being the term epigenetics was later defined as heritable changes in gene expression that are not due to any alteration in the DNA sequence 1 . The best-known epigenetic markers are DNA methylation and histone acetylation. Moreover all these phenomena are finely regulated in different manners such as through microRNAs miRNAs 2 . Waldenstrom s Macroglobulinemia WM is a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the bone marrow BM and a monoclonal immunoglobulin M in the circulation 3 4 . The most common risk factor for WM is IgM MGUS monoclonal gammopathy of undermined significance which is associated with the presence of a small IgM protein in the circulation and minimal involvement 10 lymphoplasmacytic cells .

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